Simultaneous gene expression profiling in human macrophages infected with Leishmania major parasites using SAGE
Identifieur interne : 000058 ( Main/Exploration ); précédent : 000057; suivant : 000059Simultaneous gene expression profiling in human macrophages infected with Leishmania major parasites using SAGE
Auteurs : Fatma Z. Guerfali [Tunisie, France] ; Dhafer Laouini [Tunisie, France] ; Lamia Guizani-Tabbane [Tunisie, France] ; Florence Ottones [France] ; Khadija Ben-Aissa [Tunisie, France] ; Alia Benkahla [Tunisie, France] ; Laurent Manchon [France] ; David Piquemal [France] ; Sondos Smandi [Tunisie, France] ; Ons Mghirbi [Tunisie, France] ; Thérèse Commes [France] ; Jacques Marti [France] ; Koussay Dellagi [Tunisie, France]Source :
- BMC Genomics [ 1471-2164 ] ; 2008.
Descripteurs français
- KwdFr :
- ARN messager (génétique), Analyse de profil d'expression de gènes (méthodes), Animaux (MeSH), Apoptose (génétique), Banque de gènes (MeSH), Chimiokines (génétique), Espace extracellulaire (parasitologie), Espace intracellulaire (parasitologie), Gènes MHC de classe I (MeSH), Gènes MHC de classe II (MeSH), Humains (MeSH), Interactions hôte-parasite (génétique), Interféron gamma (génétique), Leishmania major (génétique), Leishmania major (physiologie), Leishmaniose cutanée (génétique), Leishmaniose cutanée (parasitologie), Macrophages (métabolisme), Macrophages (parasitologie), Protéines S100 (génétique), Réaction de polymérisation en chaîne (MeSH), Régulation de l'expression des gènes (MeSH), Séquence nucléotidique (MeSH).
- MESH :
- génétique : ARN messager, Apoptose, Chimiokines, Interactions hôte-parasite, Interféron gamma, Leishmania major, Leishmaniose cutanée, Protéines S100.
- métabolisme : Macrophages.
- méthodes : Analyse de profil d'expression de gènes.
- parasitologie : Espace extracellulaire, Espace intracellulaire, Leishmaniose cutanée, Macrophages.
- physiologie : Leishmania major.
- Animaux, Banque de gènes, Gènes MHC de classe I, Gènes MHC de classe II, Humains, Réaction de polymérisation en chaîne, Régulation de l'expression des gènes, Séquence nucléotidique.
English descriptors
- KwdEn :
- Animals (MeSH), Apoptosis (genetics), Base Sequence (MeSH), Chemokines (genetics), Extracellular Space (parasitology), Gene Expression Profiling (methods), Gene Expression Regulation (MeSH), Gene Library (MeSH), Genes, MHC Class I (MeSH), Genes, MHC Class II (MeSH), Host-Parasite Interactions (genetics), Humans (MeSH), Interferon-gamma (genetics), Intracellular Space (parasitology), Leishmania major (genetics), Leishmania major (physiology), Leishmaniasis, Cutaneous (genetics), Leishmaniasis, Cutaneous (parasitology), Macrophages (metabolism), Macrophages (parasitology), Polymerase Chain Reaction (MeSH), RNA, Messenger (genetics), S100 Proteins (genetics).
- MESH :
- chemical , genetics : Chemokines, Interferon-gamma, RNA, Messenger, S100 Proteins.
- genetics : Apoptosis, Host-Parasite Interactions, Leishmania major, Leishmaniasis, Cutaneous.
- metabolism : Macrophages.
- methods : Gene Expression Profiling.
- parasitology : Extracellular Space, Intracellular Space, Leishmaniasis, Cutaneous, Macrophages.
- physiology : Leishmania major.
- Animals, Base Sequence, Gene Expression Regulation, Gene Library, Genes, MHC Class I, Genes, MHC Class II, Humans, Polymerase Chain Reaction.
Abstract
To investigate this host-parasite conflict at the transcriptional level, in the context of monocyte-derived human MΦs (MDM) infection by
After extracting mRNA from resting human MΦs,
Dual SAGE transcriptome analysis provided a useful, powerful and accurate approach to discriminating genes of human or parasitic origin in
Url:
DOI: 10.1186/1471-2164-9-238
PubMed: 18495030
PubMed Central: 2430024
Affiliations:
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Le document en format XML
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parasites using SAGE</title>
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<author><name sortKey="Ben Aissa, Khadija" sort="Ben Aissa, Khadija" uniqKey="Ben Aissa K" first="Khadija" last="Ben-Aissa">Khadija Ben-Aissa</name>
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<author><name sortKey="Smandi, Sondos" sort="Smandi, Sondos" uniqKey="Smandi S" first="Sondos" last="Smandi">Sondos Smandi</name>
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<author><name sortKey="Marti, Jacques" sort="Marti, Jacques" uniqKey="Marti J" first="Jacques" last="Marti">Jacques Marti</name>
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<author><name sortKey="Dellagi, Koussay" sort="Dellagi, Koussay" uniqKey="Dellagi K" first="Koussay" last="Dellagi">Koussay Dellagi</name>
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parasites using SAGE</title>
<author><name sortKey="Guerfali, Fatma Z" sort="Guerfali, Fatma Z" uniqKey="Guerfali F" first="Fatma Z" last="Guerfali">Fatma Z. Guerfali</name>
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<affiliation wicri:level="1"><nlm:aff id="I2">Laboratoire International Associé (LIA) "Ingénierie Biomoléculaire", Centre National de Recherche Scientifique (CNRS), France</nlm:aff>
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<author><name sortKey="Laouini, Dhafer" sort="Laouini, Dhafer" uniqKey="Laouini D" first="Dhafer" last="Laouini">Dhafer Laouini</name>
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<affiliation wicri:level="1"><nlm:aff id="I2">Laboratoire International Associé (LIA) "Ingénierie Biomoléculaire", Centre National de Recherche Scientifique (CNRS), France</nlm:aff>
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<author><name sortKey="Guizani Tabbane, Lamia" sort="Guizani Tabbane, Lamia" uniqKey="Guizani Tabbane L" first="Lamia" last="Guizani-Tabbane">Lamia Guizani-Tabbane</name>
<affiliation wicri:level="1"><nlm:aff id="I1">Laboratoire d'Immuno-Pathologie, Vaccinologie et Génétique Moléculaire (LIVGM), WHO Collaborating Center for Research and Training in Leishmaniasis, Institut Pasteur de Tunis, 13 place Pasteur, BP 74, 1002 Tunis-Belvédère, Tunisia</nlm:aff>
<country xml:lang="fr">Tunisie</country>
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<author><name sortKey="Ottones, Florence" sort="Ottones, Florence" uniqKey="Ottones F" first="Florence" last="Ottones">Florence Ottones</name>
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<wicri:regionArea>Laboratoire International Associé (LIA) "Ingénierie Biomoléculaire", Centre National de Recherche Scientifique (CNRS)</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="I3">Groupe d'Etude des Transcriptomes (GET), Institut de Génétique Humaine, UPR CNRS 1142, 141, rue de la Cardonille, Montpellier cedex5, 34396, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Groupe d'Etude des Transcriptomes (GET), Institut de Génétique Humaine, UPR CNRS 1142, 141, rue de la Cardonille, Montpellier cedex5, 34396</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ben Aissa, Khadija" sort="Ben Aissa, Khadija" uniqKey="Ben Aissa K" first="Khadija" last="Ben-Aissa">Khadija Ben-Aissa</name>
<affiliation wicri:level="1"><nlm:aff id="I1">Laboratoire d'Immuno-Pathologie, Vaccinologie et Génétique Moléculaire (LIVGM), WHO Collaborating Center for Research and Training in Leishmaniasis, Institut Pasteur de Tunis, 13 place Pasteur, BP 74, 1002 Tunis-Belvédère, Tunisia</nlm:aff>
<country xml:lang="fr">Tunisie</country>
<wicri:regionArea>Laboratoire d'Immuno-Pathologie, Vaccinologie et Génétique Moléculaire (LIVGM), WHO Collaborating Center for Research and Training in Leishmaniasis, Institut Pasteur de Tunis, 13 place Pasteur, BP 74, 1002 Tunis-Belvédère</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="I2">Laboratoire International Associé (LIA) "Ingénierie Biomoléculaire", Centre National de Recherche Scientifique (CNRS), France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Laboratoire International Associé (LIA) "Ingénierie Biomoléculaire", Centre National de Recherche Scientifique (CNRS)</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Benkahla, Alia" sort="Benkahla, Alia" uniqKey="Benkahla A" first="Alia" last="Benkahla">Alia Benkahla</name>
<affiliation wicri:level="1"><nlm:aff id="I1">Laboratoire d'Immuno-Pathologie, Vaccinologie et Génétique Moléculaire (LIVGM), WHO Collaborating Center for Research and Training in Leishmaniasis, Institut Pasteur de Tunis, 13 place Pasteur, BP 74, 1002 Tunis-Belvédère, Tunisia</nlm:aff>
<country xml:lang="fr">Tunisie</country>
<wicri:regionArea>Laboratoire d'Immuno-Pathologie, Vaccinologie et Génétique Moléculaire (LIVGM), WHO Collaborating Center for Research and Training in Leishmaniasis, Institut Pasteur de Tunis, 13 place Pasteur, BP 74, 1002 Tunis-Belvédère</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="I2">Laboratoire International Associé (LIA) "Ingénierie Biomoléculaire", Centre National de Recherche Scientifique (CNRS), France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Laboratoire International Associé (LIA) "Ingénierie Biomoléculaire", Centre National de Recherche Scientifique (CNRS)</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Manchon, Laurent" sort="Manchon, Laurent" uniqKey="Manchon L" first="Laurent" last="Manchon">Laurent Manchon</name>
<affiliation wicri:level="1"><nlm:aff id="I4">Skuld-Tech, 88, cour des Camisards, Montpellier, 34080, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Skuld-Tech, 88, cour des Camisards, Montpellier, 34080</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Piquemal, David" sort="Piquemal, David" uniqKey="Piquemal D" first="David" last="Piquemal">David Piquemal</name>
<affiliation wicri:level="1"><nlm:aff id="I4">Skuld-Tech, 88, cour des Camisards, Montpellier, 34080, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Skuld-Tech, 88, cour des Camisards, Montpellier, 34080</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Smandi, Sondos" sort="Smandi, Sondos" uniqKey="Smandi S" first="Sondos" last="Smandi">Sondos Smandi</name>
<affiliation wicri:level="1"><nlm:aff id="I1">Laboratoire d'Immuno-Pathologie, Vaccinologie et Génétique Moléculaire (LIVGM), WHO Collaborating Center for Research and Training in Leishmaniasis, Institut Pasteur de Tunis, 13 place Pasteur, BP 74, 1002 Tunis-Belvédère, Tunisia</nlm:aff>
<country xml:lang="fr">Tunisie</country>
<wicri:regionArea>Laboratoire d'Immuno-Pathologie, Vaccinologie et Génétique Moléculaire (LIVGM), WHO Collaborating Center for Research and Training in Leishmaniasis, Institut Pasteur de Tunis, 13 place Pasteur, BP 74, 1002 Tunis-Belvédère</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="I2">Laboratoire International Associé (LIA) "Ingénierie Biomoléculaire", Centre National de Recherche Scientifique (CNRS), France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Laboratoire International Associé (LIA) "Ingénierie Biomoléculaire", Centre National de Recherche Scientifique (CNRS)</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mghirbi, Ons" sort="Mghirbi, Ons" uniqKey="Mghirbi O" first="Ons" last="Mghirbi">Ons Mghirbi</name>
<affiliation wicri:level="1"><nlm:aff id="I1">Laboratoire d'Immuno-Pathologie, Vaccinologie et Génétique Moléculaire (LIVGM), WHO Collaborating Center for Research and Training in Leishmaniasis, Institut Pasteur de Tunis, 13 place Pasteur, BP 74, 1002 Tunis-Belvédère, Tunisia</nlm:aff>
<country xml:lang="fr">Tunisie</country>
<wicri:regionArea>Laboratoire d'Immuno-Pathologie, Vaccinologie et Génétique Moléculaire (LIVGM), WHO Collaborating Center for Research and Training in Leishmaniasis, Institut Pasteur de Tunis, 13 place Pasteur, BP 74, 1002 Tunis-Belvédère</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="I2">Laboratoire International Associé (LIA) "Ingénierie Biomoléculaire", Centre National de Recherche Scientifique (CNRS), France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Laboratoire International Associé (LIA) "Ingénierie Biomoléculaire", Centre National de Recherche Scientifique (CNRS)</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Commes, Therese" sort="Commes, Therese" uniqKey="Commes T" first="Thérèse" last="Commes">Thérèse Commes</name>
<affiliation wicri:level="1"><nlm:aff id="I2">Laboratoire International Associé (LIA) "Ingénierie Biomoléculaire", Centre National de Recherche Scientifique (CNRS), France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Laboratoire International Associé (LIA) "Ingénierie Biomoléculaire", Centre National de Recherche Scientifique (CNRS)</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="I3">Groupe d'Etude des Transcriptomes (GET), Institut de Génétique Humaine, UPR CNRS 1142, 141, rue de la Cardonille, Montpellier cedex5, 34396, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Groupe d'Etude des Transcriptomes (GET), Institut de Génétique Humaine, UPR CNRS 1142, 141, rue de la Cardonille, Montpellier cedex5, 34396</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Marti, Jacques" sort="Marti, Jacques" uniqKey="Marti J" first="Jacques" last="Marti">Jacques Marti</name>
<affiliation wicri:level="1"><nlm:aff id="I2">Laboratoire International Associé (LIA) "Ingénierie Biomoléculaire", Centre National de Recherche Scientifique (CNRS), France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Laboratoire International Associé (LIA) "Ingénierie Biomoléculaire", Centre National de Recherche Scientifique (CNRS)</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="I3">Groupe d'Etude des Transcriptomes (GET), Institut de Génétique Humaine, UPR CNRS 1142, 141, rue de la Cardonille, Montpellier cedex5, 34396, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Groupe d'Etude des Transcriptomes (GET), Institut de Génétique Humaine, UPR CNRS 1142, 141, rue de la Cardonille, Montpellier cedex5, 34396</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Dellagi, Koussay" sort="Dellagi, Koussay" uniqKey="Dellagi K" first="Koussay" last="Dellagi">Koussay Dellagi</name>
<affiliation wicri:level="1"><nlm:aff id="I1">Laboratoire d'Immuno-Pathologie, Vaccinologie et Génétique Moléculaire (LIVGM), WHO Collaborating Center for Research and Training in Leishmaniasis, Institut Pasteur de Tunis, 13 place Pasteur, BP 74, 1002 Tunis-Belvédère, Tunisia</nlm:aff>
<country xml:lang="fr">Tunisie</country>
<wicri:regionArea>Laboratoire d'Immuno-Pathologie, Vaccinologie et Génétique Moléculaire (LIVGM), WHO Collaborating Center for Research and Training in Leishmaniasis, Institut Pasteur de Tunis, 13 place Pasteur, BP 74, 1002 Tunis-Belvédère</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="I2">Laboratoire International Associé (LIA) "Ingénierie Biomoléculaire", Centre National de Recherche Scientifique (CNRS), France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Laboratoire International Associé (LIA) "Ingénierie Biomoléculaire", Centre National de Recherche Scientifique (CNRS)</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series><title level="j">BMC Genomics</title>
<idno type="eISSN">1471-2164</idno>
<imprint><date when="2008">2008</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals (MeSH)</term>
<term>Apoptosis (genetics)</term>
<term>Base Sequence (MeSH)</term>
<term>Chemokines (genetics)</term>
<term>Extracellular Space (parasitology)</term>
<term>Gene Expression Profiling (methods)</term>
<term>Gene Expression Regulation (MeSH)</term>
<term>Gene Library (MeSH)</term>
<term>Genes, MHC Class I (MeSH)</term>
<term>Genes, MHC Class II (MeSH)</term>
<term>Host-Parasite Interactions (genetics)</term>
<term>Humans (MeSH)</term>
<term>Interferon-gamma (genetics)</term>
<term>Intracellular Space (parasitology)</term>
<term>Leishmania major (genetics)</term>
<term>Leishmania major (physiology)</term>
<term>Leishmaniasis, Cutaneous (genetics)</term>
<term>Leishmaniasis, Cutaneous (parasitology)</term>
<term>Macrophages (metabolism)</term>
<term>Macrophages (parasitology)</term>
<term>Polymerase Chain Reaction (MeSH)</term>
<term>RNA, Messenger (genetics)</term>
<term>S100 Proteins (genetics)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>ARN messager (génétique)</term>
<term>Analyse de profil d'expression de gènes (méthodes)</term>
<term>Animaux (MeSH)</term>
<term>Apoptose (génétique)</term>
<term>Banque de gènes (MeSH)</term>
<term>Chimiokines (génétique)</term>
<term>Espace extracellulaire (parasitologie)</term>
<term>Espace intracellulaire (parasitologie)</term>
<term>Gènes MHC de classe I (MeSH)</term>
<term>Gènes MHC de classe II (MeSH)</term>
<term>Humains (MeSH)</term>
<term>Interactions hôte-parasite (génétique)</term>
<term>Interféron gamma (génétique)</term>
<term>Leishmania major (génétique)</term>
<term>Leishmania major (physiologie)</term>
<term>Leishmaniose cutanée (génétique)</term>
<term>Leishmaniose cutanée (parasitologie)</term>
<term>Macrophages (métabolisme)</term>
<term>Macrophages (parasitologie)</term>
<term>Protéines S100 (génétique)</term>
<term>Réaction de polymérisation en chaîne (MeSH)</term>
<term>Régulation de l'expression des gènes (MeSH)</term>
<term>Séquence nucléotidique (MeSH)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Chemokines</term>
<term>Interferon-gamma</term>
<term>RNA, Messenger</term>
<term>S100 Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Apoptosis</term>
<term>Host-Parasite Interactions</term>
<term>Leishmania major</term>
<term>Leishmaniasis, Cutaneous</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>ARN messager</term>
<term>Apoptose</term>
<term>Chimiokines</term>
<term>Interactions hôte-parasite</term>
<term>Interféron gamma</term>
<term>Leishmania major</term>
<term>Leishmaniose cutanée</term>
<term>Protéines S100</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Macrophages</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Gene Expression Profiling</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Macrophages</term>
</keywords>
<keywords scheme="MESH" qualifier="méthodes" xml:lang="fr"><term>Analyse de profil d'expression de gènes</term>
</keywords>
<keywords scheme="MESH" qualifier="parasitologie" xml:lang="fr"><term>Espace extracellulaire</term>
<term>Espace intracellulaire</term>
<term>Leishmaniose cutanée</term>
<term>Macrophages</term>
</keywords>
<keywords scheme="MESH" qualifier="parasitology" xml:lang="en"><term>Extracellular Space</term>
<term>Intracellular Space</term>
<term>Leishmaniasis, Cutaneous</term>
<term>Macrophages</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Leishmania major</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Leishmania major</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Base Sequence</term>
<term>Gene Expression Regulation</term>
<term>Gene Library</term>
<term>Genes, MHC Class I</term>
<term>Genes, MHC Class II</term>
<term>Humans</term>
<term>Polymerase Chain Reaction</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Banque de gènes</term>
<term>Gènes MHC de classe I</term>
<term>Gènes MHC de classe II</term>
<term>Humains</term>
<term>Réaction de polymérisation en chaîne</term>
<term>Régulation de l'expression des gènes</term>
<term>Séquence nucléotidique</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p><italic>Leishmania </italic>
(<italic>L</italic>
) are intracellular protozoan parasites that are able to survive and replicate within the harsh and potentially hostile phagolysosomal environment of mammalian mononuclear phagocytes. A complex interplay then takes place between the macrophage (MΦ) striving to eliminate the pathogen and the parasite struggling for its own survival.</p>
<p>To investigate this host-parasite conflict at the transcriptional level, in the context of monocyte-derived human MΦs (MDM) infection by <italic>L. major </italic>
metacyclic promastigotes, the quantitative technique of serial analysis of gene expression (SAGE) was used.</p>
</sec>
<sec><title>Results</title>
<p>After extracting mRNA from resting human MΦs, <italic>Leishmania</italic>
-infected human MΦs and <italic>L. major </italic>
parasites, three SAGE libraries were constructed and sequenced generating up to 28,173; 57,514 and 33,906 tags respectively (corresponding to 12,946; 23,442 and 9,530 unique tags). Using computational data analysis and direct comparison to 357,888 publicly available experimental human tags, the parasite and the host cell transcriptomes were then simultaneously characterized from the mixed cellular extract, confidently discriminating host from parasite transcripts. This procedure led us to reliably assign 3,814 tags to MΦs' and 3,666 tags to <italic>L. major </italic>
parasites transcripts. We focused on these, showing significant changes in their expression that are likely to be relevant to the pathogenesis of parasite infection: (i) human MΦs genes, belonging to key immune response proteins (e.g., IFNγ pathway, S100 and chemokine families) and (ii) a group of <italic>Leishmania </italic>
genes showing a preferential expression at the parasite's intra-cellular developing stage.</p>
</sec>
<sec><title>Conclusion</title>
<p>Dual SAGE transcriptome analysis provided a useful, powerful and accurate approach to discriminating genes of human or parasitic origin in <italic>Leishmania</italic>
-infected human MΦs. The findings presented in this work suggest that the <italic>Leishmania </italic>
parasite modulates key transcripts in human MΦs that may be beneficial for its establishment and survival. Furthermore, these results provide an overview of gene expression at two developmental stages of the parasite, namely metacyclic promastigotes and intracellular amastigotes and indicate a broad difference between their transcriptomic profiles. Finally, our reported set of expressed genes will be useful in future rounds of data mining and gene annotation.</p>
</sec>
</div>
</front>
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</back>
</TEI>
<affiliations><list><country><li>France</li>
<li>Tunisie</li>
</country>
</list>
<tree><country name="Tunisie"><noRegion><name sortKey="Guerfali, Fatma Z" sort="Guerfali, Fatma Z" uniqKey="Guerfali F" first="Fatma Z" last="Guerfali">Fatma Z. Guerfali</name>
</noRegion>
<name sortKey="Ben Aissa, Khadija" sort="Ben Aissa, Khadija" uniqKey="Ben Aissa K" first="Khadija" last="Ben-Aissa">Khadija Ben-Aissa</name>
<name sortKey="Benkahla, Alia" sort="Benkahla, Alia" uniqKey="Benkahla A" first="Alia" last="Benkahla">Alia Benkahla</name>
<name sortKey="Dellagi, Koussay" sort="Dellagi, Koussay" uniqKey="Dellagi K" first="Koussay" last="Dellagi">Koussay Dellagi</name>
<name sortKey="Guizani Tabbane, Lamia" sort="Guizani Tabbane, Lamia" uniqKey="Guizani Tabbane L" first="Lamia" last="Guizani-Tabbane">Lamia Guizani-Tabbane</name>
<name sortKey="Laouini, Dhafer" sort="Laouini, Dhafer" uniqKey="Laouini D" first="Dhafer" last="Laouini">Dhafer Laouini</name>
<name sortKey="Mghirbi, Ons" sort="Mghirbi, Ons" uniqKey="Mghirbi O" first="Ons" last="Mghirbi">Ons Mghirbi</name>
<name sortKey="Smandi, Sondos" sort="Smandi, Sondos" uniqKey="Smandi S" first="Sondos" last="Smandi">Sondos Smandi</name>
</country>
<country name="France"><noRegion><name sortKey="Guerfali, Fatma Z" sort="Guerfali, Fatma Z" uniqKey="Guerfali F" first="Fatma Z" last="Guerfali">Fatma Z. Guerfali</name>
</noRegion>
<name sortKey="Ben Aissa, Khadija" sort="Ben Aissa, Khadija" uniqKey="Ben Aissa K" first="Khadija" last="Ben-Aissa">Khadija Ben-Aissa</name>
<name sortKey="Benkahla, Alia" sort="Benkahla, Alia" uniqKey="Benkahla A" first="Alia" last="Benkahla">Alia Benkahla</name>
<name sortKey="Commes, Therese" sort="Commes, Therese" uniqKey="Commes T" first="Thérèse" last="Commes">Thérèse Commes</name>
<name sortKey="Commes, Therese" sort="Commes, Therese" uniqKey="Commes T" first="Thérèse" last="Commes">Thérèse Commes</name>
<name sortKey="Dellagi, Koussay" sort="Dellagi, Koussay" uniqKey="Dellagi K" first="Koussay" last="Dellagi">Koussay Dellagi</name>
<name sortKey="Guizani Tabbane, Lamia" sort="Guizani Tabbane, Lamia" uniqKey="Guizani Tabbane L" first="Lamia" last="Guizani-Tabbane">Lamia Guizani-Tabbane</name>
<name sortKey="Laouini, Dhafer" sort="Laouini, Dhafer" uniqKey="Laouini D" first="Dhafer" last="Laouini">Dhafer Laouini</name>
<name sortKey="Manchon, Laurent" sort="Manchon, Laurent" uniqKey="Manchon L" first="Laurent" last="Manchon">Laurent Manchon</name>
<name sortKey="Marti, Jacques" sort="Marti, Jacques" uniqKey="Marti J" first="Jacques" last="Marti">Jacques Marti</name>
<name sortKey="Marti, Jacques" sort="Marti, Jacques" uniqKey="Marti J" first="Jacques" last="Marti">Jacques Marti</name>
<name sortKey="Mghirbi, Ons" sort="Mghirbi, Ons" uniqKey="Mghirbi O" first="Ons" last="Mghirbi">Ons Mghirbi</name>
<name sortKey="Ottones, Florence" sort="Ottones, Florence" uniqKey="Ottones F" first="Florence" last="Ottones">Florence Ottones</name>
<name sortKey="Ottones, Florence" sort="Ottones, Florence" uniqKey="Ottones F" first="Florence" last="Ottones">Florence Ottones</name>
<name sortKey="Piquemal, David" sort="Piquemal, David" uniqKey="Piquemal D" first="David" last="Piquemal">David Piquemal</name>
<name sortKey="Smandi, Sondos" sort="Smandi, Sondos" uniqKey="Smandi S" first="Sondos" last="Smandi">Sondos Smandi</name>
</country>
</tree>
</affiliations>
</record>
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